Disruption of amyloid-derived peptide assemblies through the controlled induction of a beta-sheet to alpha-helix transformation: application of the switch concept
2007
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Résumé
Reversal of amyloid formation through a controlled induced transformation from beta-sheet to sol. alpha-helix structures through the use of a switch element S could have an important consequences understanding the mechanisms of amyloid formation and clearance.
Détails
Titre
Disruption of amyloid-derived peptide assemblies through the controlled induction of a beta-sheet to alpha-helix transformation: application of the switch concept
Auteur(s)
Mimna, Richard ; Camus, Marie-Stephanie ; Schmid, Adrian ; Tuchscherer, Gabriele ; Lashuel, Hilal A. ; Mutter, Manfred
Publié dans
Angewandte Chemie, International Edition
Volume
46
Numéro
15
Pages
2681-2684
Date
2007
Mots-clés (libres)
Conformational transition; Self-assembly; alpha-Helix; beta-Sheet (disruption of amyloid-derived peptide assemblies through the controlled induction of a beta-sheet to alpha-helix transformation); Amyloid Role: BSU (Biological study; unclassified); PRP (Properties); BIOL (Biological study) (disruption of amyloid-derived peptide assemblies through the controlled induction of a beta-sheet to alpha-helix transformation); Conformation; Secondary structure (protein; disruption of amyloid-derived peptide assemblies through the controlled induction of a beta-sheet to alpha-helix transformation); amyloid peptide beta sheet alpha helix secondary structure
Note
Reversal of amyloid formation through a controlled induced transformation from beta-sheet to sol. alpha-helix structures through the use of a switch element S could have an important consequences understanding the mechanisms of amyloid formation and clearance.
Autres identifiant(s)
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Le document apparaît dans
Production scientifique et compétences > SV - Faculté des sciences de la vie > BMI - Institut des neurosciences > LMNN - Laboratoire de neurobiologie moléculaire et neuroprotéomique
Production scientifique et compétences > SB - Faculté des sciences de base > SB Archives > LCBP - Laboratoire de chimie biomimétique et des peptides
Publications validées par des pairs
Travail produit à l'EPFL
Articles de journaux
Publié
Production scientifique et compétences > SB - Faculté des sciences de base > SB Archives > LCBP - Laboratoire de chimie biomimétique et des peptides
Publications validées par des pairs
Travail produit à l'EPFL
Articles de journaux
Publié
Date de création de la notice
2007-07-31