Switch-peptides as tool for the study of fibrillogenesis
Mutter, Manfred; Tuchscherer, Gabriele
2006

Abstract

The invention discloses a method for the manuf. of a peptidic folding precursor (switch-peptide) stable and sol. at physiol. conditions, derived from a peptide having a potential for self-assembling and fibrillogenesis. Another object of the invention is to provide a tool for the quant., controlled in vitro study of fibrillogenesis and its inhibition of peptides involved in degenerative diseases. Prepn. of peptides is described.

Details

Title Switch-peptides as tool for the study of fibrillogenesis
Author(s) Mutter, Manfred ; Tuchscherer, Gabriele
Date 2006
Keywords
Functional groups (Nvoc; switch-peptides for study of fibrillogenesis and for drug screening); Enzymes Role: BUU (Biological use unclassified); CAT (Catalyst use); BIOL (Biological study); USES (Uses) (Phenacylase; switch-peptides for study of fibrillogenesis and for drug screening); Oligomers Role: ADV (Adverse effect including toxicity); BSU (Biological study unclassified); PRP (Properties); BIOL (Biological study) (and plaques; switch-peptides for study of fibrillogenesis and for drug screening); Peptides Role: BUU (Biological use unclassified); PRP (Properties); THU (Therapeutic use); BIOL (Biological study); USES (Uses) (compds.; switch-peptides for study of fibrillogenesis and for drug screening); Disease (degenerative; switch-peptides for study of fibrillogenesis and for drug screening); Proteins Role: ADV (Adverse effect including toxicity); BSU (Biological study unclassified); BIOL (Biological study) (huntingtin; switch-peptides for study of fibrillogenesis and for drug screening); Polymerization (oligomerization; switch-peptides for study of fibrillogenesis and for drug screening); Solid phase synthesis (peptide; switch-peptides for study of fibrillogenesis and for drug screening); Aggregation; Chemical library; Conformation; Conformational transition; Drug screening; Fibril; Photolysis; Self-assembly; pH; beta-Sheet (switch-peptides for study of fibrillogenesis and for drug screening); Prion proteins Role: ADV (Adverse effect including toxicity); BSU (Biological study unclassified); BIOL (Biological study) (switch-peptides for study of fibrillogenesis and for drug screening); Amino acids Role: BSU (Biological study unclassified); BIOL (Biological study) (switch-peptides for study of fibrillogenesis and for drug screening); Enzymes Role: BUU (Biological use unclassified); CAT (Catalyst use); BIOL (Biological study); USES (Uses) (switch-peptides for study of fibrillogenesis and for drug screening); Peptides Role: BUU (Biological use unclassified); PRP (Properties); THU (Therapeutic use); BIOL (Biological study); USES (Uses) (switch-peptides for study of fibrillogenesis and for drug screening); Acyl groups (transfer; switch-peptides for study of fibrillogenesis and for drug screening); Amyloid Role: ADV (Adverse effect including toxicity); BSU (Biological study unclassified); BIOL (Biological study) (beta-; switch-peptides for study of fibrillogenesis and for drug screening); degenerative disease; drug screening; switch peptide; self assembly; fibrillogenesis; TTO:6.0588
Note Alternative title(s) : (de) Switch-peptide als tool für die untersuchung der fibrillogenese (fr) Peptides switch utilises en tant qu'outil pour l'etude de la fibrillogenese
Other identifier(s) EPO Family ID: 37331126
Patent number(s) US2010152418 (A1)
EP1907416 (A2)
WO2006136906 (B1)
WO2006136906 (A3)
WO2006136906 (A2)
Laboratories LCBP
TTO
Record Appears in Scientific production and competences > SB - School of Basic Sciences > SB Archives > LCBP - Laboratory of biomimetic and peptide chemistry
Scientific production and competences > Non-academic units > TTO - Technology Transfer Office
Work produced at EPFL
Patents
Record creation date 2007-07-31