Synthesis and chemical transformations of diazolyl alpha,alpha-difluoroacetates
2020
Abstract
Optimized protocols for the synthesis of diazolyl alpha,alpha-difluoroacetates via deoxofluorination of the corresponding glyoxylates with Morph-DAST are described. The method allowed the preparation of the title fluoridated building blocks in 73-96 % yield on up to 15 g scale. Utility of the hetaryl alpha,alpha-difluoroacetates was demonstrated by the synthesis of advanced building blocks for medicinal chemistry, i.e. carboxylic acids, amides, nitriles, and alcohols.
Details
Title
Synthesis and chemical transformations of diazolyl alpha,alpha-difluoroacetates
Author(s)
Geraschenko, Oleksandr V. ; Solomin, Vitalii V. ; Vashchenko, Bohdan V. ; Khodakivskyi, Pavlo ; Tolmachev, Andrey A. ; Grygorenko, Oleksandr O.
Published in
Journal Of Fluorine Chemistry
Volume
229
Pages
109407
Date
2020-01-01
Publisher
Lausanne, ELSEVIER SCIENCE SA
ISSN
0022-1139
1873-3328
1873-3328
Keywords
Other identifier(s)
View record in Web of Science
Laboratories
LCBIM
Record Appears in
Scientific production and competences > SB - School of Basic Sciences > SB Archives > LCBIM - Neva Chair of Bioorganic Chemistry and Molecular Imaging
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date
2020-03-03