Amino acid-based H2S donors: N-thiocarboxyanhydrides that release H2S with innocuous byproducts
2021
Abstract
A library of N-thiocarboxyanhydrides (NTAs) derived from natural amino acids with benign byproducts and controlled H2S-release kinetics is reported. Minimal acute in vitro toxicity was observed in multiple cell lines, while longer-term toxicity in cancer cells was observed, with slow-releasing donors exhibiting the greatest cytotoxic effects.
Details
Title
Amino acid-based H2S donors: N-thiocarboxyanhydrides that release H2S with innocuous byproducts
Author(s)
Kaur, Kuljeet ; Enders, Patrick ; Zhu, Yumeng ; Bratton, Abigail F. ; Powell, Chadwick R. ; Kashfi, Khosrow ; Matson, John B.
Published in
Chemical Communications
Volume
57
Pages
5522-5525
Date
2021-05-06
ISSN
1359-7345
1364-548X
1364-548X
Other identifier(s)
View record in Web of Science
Laboratories
IMX
Record Appears in
Scientific production and competences > STI - School of Engineering > IMX - Institute of Materials > UNATTRIBUTED-IMX - IMX - Unattributed publications
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date
2021-05-22