Bioluminescent compositions and uses thereof
2021
Abstract
Compositions and methods for non-invasively monitoring the intracellular processing of a biomolecule are provided. The compositions have a novel thio-luciferin moiety which can be conjugated to the biomolecule directly or via a linker such as disulfide bond wherein the luminescent (such as thio-luciferin) or pro-luminescent (such as thio-cyanobenzothiazoles) moiety is released upon reduction of the disulfide bond upon cytosolic internalization.
Details
Title
Bioluminescent compositions and uses thereof
Author(s)
Goun, Elena ; Khodakivskyi, Pavlo ; Drefahl, Manuel ; Yevtodiyenko, Aleksey ; Karatas, Hacer
Date
2021
Keywords
Note
Alternative title(s) : (fr) Compositions bioluminescentes et leurs utilisations
Other identifier(s)
EPO Family ID: 75143673
Patent number(s)
WO2021152393 (A1)
Record Appears in
Scientific production and competences > SB - School of Basic Sciences > SB Archives > LCBIM - Neva Chair of Bioorganic Chemistry and Molecular Imaging
Scientific production and competences > Non-academic units > TTO - Technology Transfer Office
Work produced at EPFL
Patents
Scientific production and competences > Non-academic units > TTO - Technology Transfer Office
Work produced at EPFL
Patents
Record creation date
2021-09-01