Cellulose nanomaterials are developing nowadays as a promising environmental friendlier biomaterial that can be extracted from native plant sources. These materials, because of their excellent physico-chemical and biological properties, urged much interest in biomedical applications. In this paper, a detailed review of nanocellulose is provided with special emphasis on greener production, demands, bio-properties and innovative application in some selected biomedical fields such as tissue implants, drug delivery systems, wound healing and biosensor applications. The current state of global commercial nanocellulose based products and their future potentials for biomedical applications are also discussed. (C) 2021 Elsevier B.V. All rights reserved.