Genomic studies indicate a novel combination therapy for follicular lymphoma COMMENT
2021
Abstract
Follicular lymphoma (FL) is an incurable form of B-cell lymphoma. Genomic alterations that inactivate RB signaling are surprisingly common in indolent FL. We show that FLs that are positive for phosphorylated RB respond to dual CDK4/BCL2 inhibition. Our results imply that RB phosphorylation identifies patients likely to benefit from such dual intervention.
Details
Title
Genomic studies indicate a novel combination therapy for follicular lymphoma COMMENT
Author(s)
Oricchio, Elisa ; Wendel, Hans-Guido
Published in
Molecular & Cellular Oncology
Volume
8
Issue
6
Pages
e969640
Date
2021-11-02
Publisher
Philadelphia, TAYLOR & FRANCIS INC
ISSN
2372-3556
Keywords
Other identifier(s)
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Laboratories
UPORICCHIO
Record Appears in
Scientific production and competences > SV - School of Life Sciences > ISREC - Swiss Institute for Experimental Cancer Research > UPORICCHIO - Prof. Oricchio Group
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date
2022-01-29