Development of cyclic peptides that can be administered orally to inhibit disease targets
Merz, Manuel Leonardo; Heinis, Christian
2023

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Abstract

Cyclic peptides can bind challenging disease targets, but their oral application is hindered by digestion and absorption issues. We developed a versatile method for the synthesis and functional screening of vast numbers of synthetic cyclic peptides and identified peptides with high inhibitory activity, stability and oral bioavailability in rats.

Details

Title Development of cyclic peptides that can be administered orally to inhibit disease targets
Author(s) Merz, Manuel Leonardo ; Heinis, Christian
Published in Nature Chemical Biology
Date 2023-12-28
Publisher Nature Portfolio, Berlin
ISSN 1552-4450
1552-4469
DOI https://doi.org/10.1038/s41589-023-01505-0
Other identifier(s) View record in Web of Science
Laboratories LPPT
Record Appears in Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LPPT - Laboratory of Therapeutic Proteins and Peptides
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date 2024-02-20

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