An autologous antigen-agnostic dendritic cell therapy that forgoes antigen loading
De Palma, Michele
2024

Abstract

We developed a method for generating dendritic cell progenitors (DCPs) from hematopoietic stem and progenitor cells isolated from bone marrow or blood. When engineered to express IL-12 and FLT3L, these DCPs reprogram the tumor microenvironment and elicit anti-tumor immunity without the need for ex vivo antigen loading.

Details

Title An autologous antigen-agnostic dendritic cell therapy that forgoes antigen loading
Author(s) De Palma, Michele
Published in Nature Cancer
Date 2024-01-03
Publisher Nature Portfolio, Berlin
ISSN 2662-1347
DOI https://doi.org/10.1038/s43018-023-00674-0
Other identifier(s) View record in Web of Science
Laboratories UPDEPALMA
Record Appears in Scientific production and competences > SV - School of Life Sciences > ISREC - Swiss Institute for Experimental Cancer Research > UPDEPALMA - Prof. De Palma Group
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Grant EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council)
Record creation date 2024-02-21